Sunday, June 17
Registration opens at 12.00
13.00 − 17.00 : PATHEMA WORKSHOP
Venue: Helsingfors (Scandinavia Sal 1)
18.15 : START OF CONFERENCE
Opening address − Anne−Brit Kolstø, University of Oslo, Norway
18.30 : STAPHYLOCOCCUS AUREUS: VIRULENCE, CARRIAGE, AND FIGHTING THE FAT
Keynote presentation − Simon J. Foster, University of Sheffield, UK
19.30 : RECEPTION
Monday, June 18
Session I: Genomics
Chairs: Paul Jackson and Jacques Mahillon
8.30 : Welcome
8.35 : A BACILLUS ANTHRACIS TILING GENECHIP FOR PRECISE GENOTYPING
P. Keim, Northern Arizona University and Translational Genomics Research Institute, USA
9.00 : WHOLE GENOME SEQUENCING OF PATHOGENIC BACILLUS CEREUS ISOLATES AND GROUP−WIDE COMPARATIVE ANALYSIS
M.J. Rosovitz, The Institute for Genomic Research (TIGR), USA
9.25 : INVESTIGATING OF BACILLUS CEREUS SENSU LATO DIVERSITY BY NOVEL GENE DISCOVERY (NGD) APPROACH THROUGH COMPARATIVE GENOMIC HYBRIDIZATION (CGH)
S.N. Peterson, The Institute for Genomic Research (TIGR), USA
9.50 : WHOLE GENOME SHOTGUN SEQUENCE OF 20 B. CEREUS GROUP STRAINS
T.D. Read, Biological Defense Research Directorate, Naval Medical Research Center, USA
10.05 : COFFEE BREAK
10.30: HOMOLOGOUS RECOMBINATION IN THE B. CEREUS SUBGROUP
R.T. Okinaka, Los Alamos National Laboratory and Northern Arizona University, USA
10.45 : METABOLIC CAPACITY OF BACILLUS CEREUS STRAINS ATCC 14579 AND ATCC 10987 INTERLINKED WITH COMPARATIVE GENOMICS
M. Mols, Wageningen Centre for Food Sciences and Wageningen University and Research Centre, The Netherlands
11.10 : GIL01 AND GIL16, A NEW GENERATION OF TECTIVIRUSES INFECTING BACILLUS THURINGIENSIS
N. Fornelos, Université Catholique de Louvain, Belgium
11.35 : COMPLETE NUCLEOTIDE SEQUENCE OF NINE INDIGENOUS PLASMIDS CARRIED BY BACILLUS THURINGIENSIS STRAIN YBT−1520
C. Liu, Huazhong Agriculture University, China
12.00 : MOBILE CHROMOSOMAL REPEAT ELEMENTS UNIQUE TO THE BACILLUS CEREUS GROUP − CHROMOSOMAL ORGANIZATION, TRANSCRIPTION, AND SECONDARY STRUCTURE
O.A. Økstad, University of Oslo, Norway
12.15 : LUNCH
Session II: Epidemiology and Ecology
Chairs: Paul Keim and Didier Lereclus
14.00 : A SUPERTREE DATABASE FOR COMBINED AND INTEGRATIVE MULTI−LOCUS SEQUENCE TYPING ANALYSIS OF THE BACILLUS CEREUS GROUP
N.J. Tourasse, University of Oslo, Norway
14.25 : ANN−ASSISTED FTIR SPECTROSCOPY, A NEW METABOLIC FINGERPRINTING METHOD FOR EPIDEMIOLOGICAL AND POPULATION STUDIES OF THE BACILLUS CEREUS GROUP
M. Ehling−Schulz, Technische Universität München, Germany
14.50 : CHARACTERIZATION OF BACILLUS ANTHRACIS−LIKE BACTERIA ISOLATED FROM AFRICAN WILD GREAT APES
S.R. Klee, Robert Koch−Institut, Germany
15.15 : EPIDEMIOLOGY OF AN ANTHRAX OUTBREAK IN CANADA IN SUMMER 2006
E.J. Golsteyn Thomas, CFIA Lethbridge Laboratory, Canada
15.30 : COFFEE BREAK
16.00 − 17.30 : DISCUSSION
18.00 : BOAT TRIP (SOCIAL PROGRAMME)
Tuesday, June 19
Session III: Bacteria−Host interaction
Chairs: Michèle Mock and Arthur Friedlander
8.30 : TRANSCRIPTIONAL PROFILING OF BACILLUS ANTHRACIS DURING INFECTION OF HOST MACROPHAGES
N.H. Bergman, University of Michigan Medical School, USA
8.55 : INTERACTIONS OF BACILLUS ANTHRACIS WITH IMMUNE CELLS: PROBING HETEROGENEOUS OUTCOMES OF INFECTION AT THE SINGLE CELL LEVEL
S.R. Blanke, University of Illinois, USA
9.20 : LUNG DENDRITIC CELLS RAPIDLY MEDIATE ANTHRAX SPORE ENTRY THROUGH THE PULMONARY ROUTE
J.−N. Tournier, Centre de Recherches du Service de Santé des Armées (CRSSA), France
9.45 : SYSTEMS BIOLOGY APPROACH TO PROTECTION AGAINST LETHAL ANTHRAX CHALLENGE
S. Popov, National Center for Biodefense and Infectious Diseases, George Mason University, USA
10.10 : COFFEE BREAK
10.30 : PRIMARY INVOLVEMENT OF PHARYNX AND PEYER’S PATCH IN INHALATIONAL AND INTESTINAL BACILLUS ANTHRACIS INFECTION
I.J. Glomski, Institut Pasteur, France
10.55 : KINETICS OF GERMINATION AND DISSEMINATION OF A SEPTICEMIC NON TOXINOGENIC BACILLUS ANTHRACIS STRAIN DURING A CUTANEOUS INFECTION IN MICE
P.L. Goossens, Institut Pasteur, France
11.20 : IDENTIFICATION OF HOST IMMUNE FACTORS INVOLVED IN PROTECTION AGAINST INHALATIONAL BACILLUS ANTHRACIS
C.L. Loving, Center for Biologics Evaluation and Research, Food and Drug Administration (FDA), USA
11.45 : PATHOGENESIS AND VIRULENCE OF BACILLUS ANTHRACIS SPORES
M.K. Swiecki, University of Alabama at Birmingham, USA
12.10 : BACILLUS ANTHRACIS SPORES OF THE bclA MUTANT ADHERE BETTER TO EPITHELIAL, FIBROBLAST, AND ENDOTHELIAL CELLS BUT NOT MACROPHAGES
J. Bozue, U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), USA
12.25 − 12.40 : DISCUSSION
12.40 : LUNCH
Session IV: Bacterial development
Chairs: Anne Moir and Les Baillie
14.00 : ROLES OF THE BACILLUS ANTHRACIS SPORE PROTEINS CotO AND SpoVID IN SPORE STRUCTURE AND FUNCTION
A. Driks, Loyola University Medical Center, USA
14.25 : NON−UNIFORM ASSEMBLY OF THE BACILLUS ANTHRACIS EXOSPORIUM AND A BOTTLECAP MODEL FOR SPORE GERMINATION AND OUTGROWTH
C.L. Turnbough Jr., University of Alabama at Birmingham, USA
14.50 : TEMPORAL CONTROLS OF SPORE GERMINATION INFULENCING ANTHRAX
P.C. Hanna, University of Michigan Medical School, USA
15.05 : CARACTERISATION AND ROLE OF THE IRON DEPENDENT INTERNALIN−LIKE PROTEIN <<ILSA>> EXPRESSED DURING INFECTION
C. Nielsen−LeRoux, Institut National de la Recherche Agronomique (INRA), France
15.30 : BACILLUS CEREUS BIOFILM PRODUCES VIRULENCE FACTORS
T. Candela, Institut National de la Recherche Agronomique (INRA), France
15.55 : BACILLUS ANTHRACIS IN VIVO SORTASE REPERTOIRE
S. Davison, Institut Pasteur, France
16.10 − 16.20 : DISCUSSION
16.30 − 18.30 : Poster Session I (84 posters from Europe, America, and Asia)
19.00 − 21.00 : RECEPTION IN THE CITY HALL
Wednesday, June 20
Session V: Gene regulation
Chairs: Agnès Fouet and Theresa Koehler
8.30 : DEVELOPMENTAL REGULATORS AND ATXA EXPRESSION IN BACILLUS ANTHRACIS
T.M. Koehler, University of Texas, Houston Health Science Center, USA
8.55 : OPPOSING EFFECTS OF HISTIDINE PHOSPHORYLATION REGULATE THE AtxA VIRULENCE TRANSCRIPTION FACTOR IN BACILLUS ANTHRACIS
M. Perego, Scripps Research Institute, USA
9.20 : THE ROLE OF THE STATIONARY PHASE REGULATOR CODY IN THE VIRULENCE OF BACILLUS ANTHRACIS
A. Fouet, Institut Pasteur, France
9.45 : CHARACTERIZATION OF A NEW QUORUM−SENSING SYSTEM IN THE BACILLUS CEREUS GROUP
D. Lereclus, Institut National de la Recherche Agronomique (INRA), France
10.00: REGULATORY ELEMENTS OF THE B. ANTHRACIS asb OPERON
S. Cendrowski, Michigan State University, USA
10.15 : COFFEE BREAK
10.45 : MICROARRAY ANALYSIS OF GENES REGULATED BY Arp1, A NEW BACILLUS ANTHRACIS TRANSCRIPTIONAL REGULATOR
R.F. Rest, Drexel University College of Medicine, USA
11.10 : DEALING WITH THE COLD; TRANSCRIPTOME ANALYSIS OF THE COLD SHOCK RESPONSE OF BACILLUS CEREUS
M. Nierop Groot, Wageningen Centre for Food Sciences and Food Technology Centre, Wageningen University and Research Centre, The Netherlands
11.35 : TRANSCRIPTIONAL PROFILING OF THE CONJUGATIVE PLASMID pAW63 REVEALS EVIDENCE OF REGULATORY CROSS−TALK WITH CROMOSOMAL REGULONS
J. Mahillon, Université Catholique de Louvain, Belgium
12.00 : THE REPX REPLICATION PROTEIN ENCODED BY PLASMID pXO1 of BACILLUS ANTHRACIS BINDS TO DNA, HAS GTPASE ACTIVITY AND FORMS FTSZ−LIKE POLYMERS
S.A. Khan, University of Pittsburgh School of Medicine, USA
12.25 − 12.40 : DISCUSSION
12.40 : LUNCH
Session VI: Toxins
Chairs: Stephen Leppla and Cesare Montecucco
14.00 : ANTHRAX EDEMA TOXIN GENERATES C−AMP GRADIENTS IN CELLS
C. Montecucco, Istituto C.N.R. Neuroscienze, Padova, Italy
14.25 : cAMP FROM BACILLUS ANTHRACIS EDEMA TOXIN ACTIVATES GSK−3B AND ENHANCES N−TERMINAL B−CATENIN PHOSPHORYLATION IN THE NUCLEUS OF MACROPHAGES
J.D. Ballard, University of Oklahoma Health Sciences Center, USA
14.50 : STRUCTURAL AND FUNCTIONAL ANALYSES OF ANTHRAX CYTOLYSIN, ANTHROLYSIN O
W.−J. Tang, University of Chicago, USA
15.15 : THE LDL RECEPTOR−RELATED PROTEINS LRP5 AND LRP6 ARE NOT REQUIRED FOR PROTECTIVE ANTIGEN−MEDIATED INTERNALIZATION OR LETHALITY OF ANTHRAX LETHAL TOXIN
J.L. Bromberg−White, Van Andel Research Institute, USA
15.40 : ANTHRAX EDEMA TOXIN SENSITIZES DBA/2J MICE TO LETHAL TOXIN
M. Moayeri, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), USA
16.05 − 16.20 : DISCUSSION
16.30 − 18.30 : Poster Session II (83 posters from Europe, America, and Asia)
18.45 − 20.00 : DISCUSSION
20.30 : BANQUET
Thursday, June 21
Session VII: Vaccines and therapy
Chairs: Avigdor Shafferman and Susan Welkos
8.30 : A SHORT COURSE OF ANTIBIOTICS IS EFFECTIVE FOR TREATMENT BUT NOT PROPHYLAXIS OF INHALATIONAL ANTHRAX IN THE NONHUMAN PRIMATE
N.J. Vietri, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), USA
8.55 : DEVELOPMENT OF AN INHALATIONAL BACILLUS ANTHRACIS EXPOSURE THERAPEUTIC MODEL IN NEW ZEALAND WHITE RABBITS
G. Meister, Battelle Biomedical Research Center, USA
9.20 : COMPREHENSIVE GENOMIC AND PROTEOMIC ANALYSES TOWARDS IDENTIFICATION OF BACILLUS ANTHRACIS VACCINE CANDIDATES
A. Shafferman, Israel Institute for Biological Research, Israel
9.45: IDENTIFICATION OF CONSERVED VACCINE TARGETS BY INTEGRATING COMPARATIVE PROTEOME PROFILING AND GENOME−BASED IN SILICO SCREENING OF SPORES OF BACILLUS CEREUS SENSU LATO
S. Mukhopadhyay, Biological Defense Research Directorate, Naval Medical Research Center, USA
10.10 : COFFEE BREAK
10.30 : IN VITRO AND IN VIVO BACTERICIDAL ACTIVITIES OF RECOMBINANT γ−PHAGE LYSIN AS WELL AS ALPHA AND THETA DEFENSINS
U.K. Hahn, University of Hohenheim, Germany
10.55 : AN UPDATE ON THE SAFETY PROFILE OF ANTHRAX VACCINE ADSORBED AS OBSERVED IN AN ONGOING HUMAN CLINICAL TRIAL
J. Wright, Centers for Disease Control and Prevention (CDC), USA
11.20 : CO−DELIVERY OF POLYMERIC MICROPARTICLES ALTERS THE IMMUNOGENICITY AND POTENCY OF ANTHRAX DNA VACCINES
L. Baillie, Cardiff University, UK
11.35 − 11.50 : DISCUSSION
12.00 : END OF CONFERENCE
